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Software Development using Artificial Intelligence

For more than ten years Chimaera has experience with machine learning algorithms. We are realizing image segmentation, classification and regression tasks with the technology of Artificial Intelligence (AI). We offer this technology in a customer-centered workflow and help you to reduce the time to market. We provide customer-based services that combine all stages necessary to incorporate AI into your applications. This comprises data annotation, network design and training on dedicated hardware, adaptations of model design, integration into your existing software as well as a technology training to achieve outstanding results and kick-start your developer team to work independently with the new technology.


Stages of our AI Services

Data Annotation

  • In-house efficient annotation tools for 2D, 3D and 4D data 
  • Annotation by our medical experts
  • Defined quality standards for annotations
  • Planning and support with data acquisition
  • Build customized anatomical data bases


  • Experience from successful past projects
  • Receive annotations in standard formats
  • Keep ownership of data and annotations

Model Design and Training

  • Custom neural network design

  • Problem-specific pre-processing

  • Dedicated high performance hardware


  • Learn from our experienced AI experts

  • Reduce engineering time

  • Fast evolving technology

Customer Integration

  • Delivery of trained model and annotated data
  • Software SDK and API (C / C++)
  • Source code of model design
  • API for hassle-free integration


  • Certified expert medical software development
  • Model reusable for future applications
  • Platform-independent software
  • CPU and GPU supported

Lifetime Management and Support

  • Refinement and adaptions during clinical use-test
  • Re-training with additional data
  • Keep model design and software up to date


  • State-of-the-art technology
  • Experience in regulatory requirements

Work Cases using AI

In this section you find some examplatory use cases we have realized in-house. You find a list with further possible applications using AI here.

Automated Organ Segmentation on MRI

In this example we realized a robust and accurate segmentation of the liver, the spleen, the kidneys and the heart in various Magnetic Resonance Imaging (MRI) sequences. The apporach has proven to cope with even non-standardized image intensities and varying contrast in MRI. All aspects of a typical AI service project have been realized in-house by our annotation and software experts. We have achieved an average DICE coefficient across the sequences of 92%.

Image Denoising with Deep Learning

In this example we realized the denoising of X-Ray images of the spine. Deep Learning techniques allow to predict the noise of an image. The predicted noise thus can be removed from an image which results in a denoised image.

Chimaera Model Compression Technology

Medical applications in computer aided diagnosis like fluoroscopy require real-time capable algorithms which can process high frame rates. In the same time there is a growing demand for image processing applications on low-end hardware like mobile devices or embedded solutions. We have developed an algorithm that in a smart way reduces the number of parameters with almost no effect on the accuracy.

We have trained and tested our algorithms with a dataset of 67 images of a seven-class segmentation problem. The target organs are: right and left lung, liver, spleen, right and left kidney. This data set was also used for a two-class-segmentation problem (i.e. differentiating tissue from background). As basis for our compressed algorithm we used the SegNetmodel.

 Number of ParametersAccuracy

Reduction of Parameters in %

SegNet7-class problem


Our Solution with reduced Parameters

SegNet 7-class problem





73.2 %


SegNet  2-class problem



Our Solution with reduced Parameters

SegNet 2-class problem


95.9 %

With our algorithm we improved the frame rate by the factor 3.5 and reduced the memory usage by more than 60%. This applications enables new possibilities especially for mobile devices and real-time solutions.

Vijay Badrinarayanan, Alex Kendall, and Roberto Cipolla. Segnet: A deep convolutional encoder-decoder architecture for image segmentation. CoRR, abs/1511.00561, 2015.

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